Do you find yourself struggling to keep track of your thoughts, skipping social gatherings and appointments, or experiencing frequent forgetfulness?
Have you always battled feelings of irritability, restlessness, insomnia, or even palpitations?
These could be signs of cognitive decline, anxiety and/or depression, all of which are more common than you might think.
According to the Centers for Disease Control and Prevention, 1 out of every 9 adults in the U.S. suffer from cognitive decline.
Similarly, the World Health Organization reports that 280 million people worldwide are affected by depression.
These conditions can lead to tragic outcomes, with over 700,000 people worldwide losing their lives to suicide due to anxiety and depressive disorders annually.
Right now, there is an urgent need for effective treatments to manage these symptoms and help individuals lead normal lives.
Enter Semax and Selank: two safe and effective peptides for improving cognitive health and alleviating anxiety.
Initially developed in Russia, these peptides are now being used by people all over the world to help them function at their best.
But if we were to pit Semax vs Selank in a head-on comparison to see which peptide is better, who wins? Or are they just meant to solve different problems?
In this article, we’ll share the roles that Semax and Selank play in cognitive health and mood enhancement.
We’ll also discuss their similarities and differences to help you decide which peptide is best for your current needs.
What are Selank and Semax Peptides?
Selank and Semax are bioactive compounds developed to help people optimize their cognitive health and provide relief from stress/anxiety.
Selank, previously known as TP-7, is a synthetic heptapeptide developed by scientists in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences.
In 2009, the Russian Federation Ministry of Health approved the peptide for human use.
Selank is available in Ukraine and Russia as a nootropic and anxiolytic drug, largely thanks to its minimal side effects and lower risk of addiction.
It works by regulating the release of stress hormones such as cortisol, helping enhance mood and reduce stress.
Semax, on the other hand, was initially developed to treat neurological disorders but was later discovered to help people boost their cognitive capabilities.
The peptide was developed in 1980 by the Institute of Molecular Genetics of the Russian Academy of Sciences as a cognitive-enhancing and neuroprotective agent, especially for patients dealing with optic nerve atrophy, encephalopathy, and ischemic stroke.
It is made up of four amino acid fragments (Met-Glu-His-Phe) and a Pro-Gly-Pro motif attached to the C-terminus.
The Met-Glu-His-Phe fragment is part of all melanocortin sequences, including adrenocorticotropic (ACTH), but it has no relationship with the hormone’s endocrine effects.
Whereas the Pro-Gly-Pro motif provides Semax with increased stability so it can pass the blood-brain barrier and reach the central nervous system.
It then works with nootropic factors in the nervous system to support the growth, survival, and maintenance of neurons.
Semax can also protect brain cells, ward off depression, and treat neurological disorders, such as attention deficit hyperactivity disorder (ADHD) and Alzheimer’s disease.
How Do Semax and Selank Work?
Semax is derived from the adrenocorticotropic hormone (ACTH) and is known for its cognitive-enhancing abilities.
It works by boosting brain-derived neurotrophic factor (BDNF) levels in the brain.
BDNF is important for the formation, maintenance, and survival of existing neurons… which helps improve memory formation, synaptic plasticity, and enhanced cognitive function.
Russian researchers found that using Semax increases BDNF levels by 1.4 times and doubles the expression of the trKB gene (tropomyosin receptor kinase B).
Thus, Semax is best used if you want to improve your memory, concentration, and problem-solving skills.
Selank, on the other hand, impacts neurotransmitter system (particularly serotonin for mood/emotion regulation).
This peptide works by binding to GABA and opioid receptors, increasing serotonin levels in the brain.
As a result, Selank can help reduce symptoms of depression, anxiety, and stress-related disorders.
Selank can also promote BDNF production, further improving memory and concentration.
In either case, these nootropic peptides provide promising results for those looking to improve their brain and emotional health.
Comparing Semax and Selank Peptides
Semax and Selank are great peptides for pain management but are also effective peptides for increasing energy levels.
But most importantly they help improve your brain health and positively affect how you feel.
Let’s compare the two and see what their best use cases are.
Semax vs Selank Benefits
As we talked about earlier, Selank helps with anxiety, depression, and other mood disorders.
In a study by Russian scientists, patients with pre-existing anxiety disorders treated with Selank experienced fewer anxiety symptoms:
“Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients).
The patient’s state was assessed with psychometric scales (Hamilton, Zung, CGI). Enkephalin activity in the blood serum was measured as well.
The anxiolytic effects of both drugs were similar but selank had also antiasthenic and psychostimulant effects.
The clinical-biological study revealed that patients with GAD and neurasthenia had a decreased level of tau(1/2) leu-enkephalin which was correlated with disease duration, severity of symptoms related to anxiety and asthenia and autonomic disorders.
The increase of this parameter and stronger positive correlations with anxiety levels were observed during the treatment with selank mostly in patients with GAD.”
In another study involving patients with phobic anxiety and somatoform disorders, those who took Selank experienced reduced anxiety levels lasting for a week alongside an overall improvement in their quality of life.
“A comparative study of the anxiolytic effect and tolerability of selank and phenazepam was carried out in 60 patients with phobic anxiety- and somatoform disorders were examined.
Pronounced anxiolytic and mild nootropic effects of selank were demonstrated. The anxiolytic effect lasted for a week after last receiving the peptide.
Selank had a positive impact on the quality of life of the patients.”
In a study published in Neuroscience and Behavioral Physiology, mice given 300 μg/kg of Selank had experienced improvements in memory and learning abilities:
“Selank administration (300 micrograms/kg) significantly activated the learning process in rats with initially poor learning ability compared to piracetam.
The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of peptide 15 min before the start of training sessions for four days.
The effects of Selank (300 microg/kg) were compared with the effects of the nootrope piracetam (400 mg/kg).
These experiments showed that Selank significantly activated the learning process in rats with initially poor learning ability, with effects apparent after the first dose on training day 1.
The effect progressively increased on repeated administration of Selank: the total number of correct solutions increased and the number of errors decreased.
The maximum optimizing activity of Selank on learning in normal rats was seen on day 3 of repeated administration and training, i.e., after the formation of the initial consolidation phase.”
According to the Journal of Bulletin of Experimental Biology and Medicine, Selank stabilizes enkephalin levels, which helps reduce stress and anxiety.
Once again, this improved learning capabilities in mice given the peptide:
“Comparative study of plasma activities of enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions revealed significant differences between intact BALB/c and C57Bl/6 mice by the half-life of plasma leu-enkephalin.
Selank in a dose of 100 micrograms/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice, but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice.
Our results suggest that the anxiolytic activity of Selank is associated with the inhibition of enkephalin-degrading enzymes.”
Apart from its anti-anxiety properties, Selank can also boost the immune system by promoting the production of immune system cells in the body.
Patients suffering from depression who were given Selank had increased IL-6 levels after 14 days of use.
(NOTE: IL6 is an inflammatory protein that protects your body from and destroys bacteria, pathogens, and other infection-causing microorganisms.)
“The experiments in vitro revealed that the drug in concentration 10-7 M completely suppressed gene expression by peripheral blood IL-6 of patients with depression but not of the healthy controls.
At the same time, a significant increase in IL-6 concentration was observed in the cell culture of peripheral blood of patients in the presence of selank.
The changes in the Th1/Th2 cytokine balance in vivo were found in the serum of patients with generalized anxiety disorder and neurasthenia who received Selank for 14 days.
The dynamics of these changes had a significant inverse correlation dependence.
The cytokine-regulating effects revealed in the study suggest that selank can be used as a novel immunomodulator in patients with anxiety-asthenic disorders.
Additionally, the adaptogenic properties of selank may be beneficial to its use in elderly people and people exposed to environmental stressors for the prevention of infectious diseases.”
Believe it or not, Selank can help improve symptoms of alcohol withdrawal.
In another study published in the Bulletin of Experimental Biology and Medicine, researchers discovered that Selank can help improve anxiety levels associated with alcohol withdrawal within 48 hours:
“We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks.
In alcohol-preferring animals (mean daily ethanol intake >5.0 g/kg) allowed the free choice between 10 % ethanol and water.
A single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption.
The findings suggest that selank is effective in eliminating alcohol withdrawal symptoms in rats.”
Moreover, growing research suggests Selank has antioxidant properties supporting liver health.
Rats given 100 and 300 μg/kg of Selank showed improved free radical levels in their liver:
“We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
Under conditions of acute restraint stress, Selank in doses of 100 and 300 μg/kg decreased catalase and superoxide dismutase activities and malondialdehyde concentration and increased total antioxidant activity in the liver homogenate.
Administration of Selank in a dose of 1000 μg/kg reduced the content of aminotransferases in blood serum, decreased superoxide dismutase activity in the liver, and increased total antioxidant activity.
Under conditions of chronic stress, Selank in all doses produced similar effects: reduced superoxide dismutase activity and malondialdehyde concentration in the liver tissue and AST activity in the serum. The other parameters remained unchanged.”
But going back to cognitive health, emerging research supports Semax’s beneficial effects on brain function.
In healthy men and women, those given intranasal Semax improved the brain’s default mode network function.
The brain’s default network is a group of regions that are more active when you’re resting compared to when you’re focusing on a specific task.
This network is believed to help with internal thoughts, like remembering the past, planning for the future, and daydreaming.
“The effects of the nootropic drug Semax on the neuronal network of the brain were studied by resting-state functional magnetic resonance imaging (resting state fMRI).
The study was carried out on two groups of healthy volunteers (11 men and 13 women aged 43.9±9.5 years).
Resting-state fMRI was carried out 3 times: directly before and 5 and 20 min after intranasal 1% Semax (14 subjects) or placebo (10 subjects).
The topography of the resting state default mode network was studied.
A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls.
Resting-state fMRI confirmed Semax’s effects on the neuronal network of the brain and demonstrated the topography of these effects.”
In another study published in the Journal of Aviakosm Ekolog Med, Russia, Semax helped treat memory disorders in white mongrel rats via elevating blood supply to the brain:
“Experiments with white mongrel rats (both females and males) showed that nootropic substances, i.e. sodium hydroxybutyrate, pyracetam, oxyracetam, aniracetam, centrophinoxine, nooglutyl, mexydol, semax, amide L-pyroglutamyl-D-alanine, and MK-801, a specific noncontesting antagonist of the NMDA-receptor complex, significantly increased survivability of the animals following bilateral occlusion of the common carotid arteries.
The nootrops prevented, partly or completely, mnestic disorders in the experimental rats.
In contrast, MK-801 profoundly aggravated these disorders. Similar results were obtained with a model of hypoxic amnesia.
Except for N-acetylglycine amide and amide L-pyroglutamyl-D-alanine, the nootrops fully or to a considerable extent blocked the development of mnestic disorders in hypoxic rats.
The authors recommend novel nootrops (nooglutyl, mexidol, semax and GVS-111) for the pharmacological correction of mnestic disorders consequent to hypoxia or cerebral ischemia.”
Semax is known for its neuroprotective properties, which help protect the brain from different types of damage and degeneration.
One key way it does this is by reducing oxidative stress that can cause damage and death to brain cells.
By lowering oxidative stress, Semax may slow down the progression of neurodegenerative conditions and protect brain cells from harm:
“Semax is the first domestic nootropic drug of an unexhausted type from the group of neuropeptides. In experimental studies it showed angioprotective, antihypoxic and neurotrophic activity in the doses 100-150 micrograms/kg.
A combined clinical-electrophysiologic study revealed its high efficiency in acute ischemic stroke.
A clinical trial was performed of immunobiochemical mechanisms of neuroprotective properties of Semax in acute period of ischemic stroke.
A retrospective comparative clinicoimmunobiochemical analysis provided objective data on the molecular level on activating influence of Semax on antiinflammatory postischemic reactions in the brain.
Shifting neuromediatory balance toward a prevalence of the antiinflammatory agents (interleukin-10, tumor necrosis factor-alpha) over the factors maintaining the inflammation (interleukin-8, C-reactive protein).”
Semax may also assist in the recovery process following traumatic brain injuries (TBIs), which usually lead to cognitive issues and neurological problems.
Semax’s ability to protect and restore the brain may aid in the healing and rebuilding of damaged brain tissue.
In fact, in 110 patients who had an ischemic stroke, those given Semax had boosted BDNF levels, improved motor performance, and faster functional recovery:
“One hundred and ten patients after IS (43 men, 67 women, mean age 58.0±9.7, Ме 63 years) were examined.
All patients were divided into early and late rehabilitation groups. Each group was subdivided into semax+ and semax- subgroups.
Standard regimen of semax included 2 courses (6000 mcg/day) for 10 days with 20 day interval.
Plasma BDNF levels, motor performance on the British Medical Research Council scale and Barthel index were assessed in all groups.
Administration of semax, regardless of the timing of rehabilitation, increased BDNF plasma levels which remained high during the whole study period.
In semax- subgroups high BDNF plasma levels were positively correlated with early rehabilitation.
Administration of semax and high BDNF levels accelerated the improvement and ameliorated the final outcome of Barthel score index.
There was a positive correlation between BDNF plasma levels and Barthel score, as well as a correlation between early rehabilitation and motor performance improvement.
The correlation between BDNF plasma levels and Barthel score was modified by the timing of rehabilitation.”
Apart from its cognitive benefits, Semax has anti-anxiety and antidepressant effects as well.
Rats that were injected with Semax showed anti-anxiety and antidepressant effects after 14 days of treatment.
This is due to the activation of the serotoninergic system in the brain and the boost of BDNF expression in the hippocampus:
“Effects of chronic intranasal administration of ACTH(4-10) analog Semax (MEHFPGP) on exploratory activity, anxiety level, and depression-like behaviour were studied in white rats.
The peptide was injected daily in dose 0.05 mg/kg during 10 or 14 days.
It was shown that chronic Semax administration at 1-2 weeks induced anxiolytic and antidepressant effects but did not influence the exploratory activity in a non-stressogenic environment.
The Semax effects may be the results of activation of the brain serotoninergic system as well as increased BDNF expression in the rat hippocampus.”
As part of the ACTH-derived peptide family, Semax can be used to treat ischemic stroke in patients 28 days after a heart attack.
In mice, Semax helps improve heart function and reduces the risk of heart failure after a heart attack.
It also reduces excessive NO production and neurological problems in rat brains caused by reduced blood flow:
“Semax (150 microg/kg) was given i. p. in the operating day twice: 15 min and 2 hours after coronary occlusion, and once a day for the following 6 days.
In 28 days after infarction, the MI group developed cardiac hypertrophy, cell growth was caused mainly by the increase of contractile filaments not supported by the appropriate mitochondrial growth that indicated an impaired energy supply of the cells.
Moreover, cardiac hypertrophy was accompanied by decreased mean arterial blood pressure and cardiac contractile function and increased left ventricular end-diastolic pressure.
Pharmacological change of cardiac afterload revealed that, in 28 days after MI, the rat heart was not able to change its contractile performance in response to either increase or decrease of systemic blood pressure, and as a result could not maintain its diastolic pressure.
All these changes obviously reflect development of heart failure.
Semax did not affect cardiac work but partially prevented end-diastolic pressure growth in left ventricle as well as ameliorated cardiomyocyte hypertrophy and disproportionate growth of contractile and mitochondrial apparatus, thus exerting beneficial effect on the left ventricular remodeling and heart failure development late after myocardial infarction.”
Not many people know Semax can increase the quantity and movement of immune cells, as well as upregulate the expression of genes related to immune function.
In a study found in the Bulletin of Experimental Biology and Medicine, Semax has been shown to help treat stress-induced immune imbalance thanks to its immune-modulating properties:
“We studied the immunocorrecting effects of Semax on the model of “social” stress caused by sensory contact and intermale confrontation.
Functional activity of the immune system of laboratory animals was evaluated in standard immunopharmacological tests: delayed-type hypersensitivity reaction, direct agglutination test, latex test for studying phagocytic activity of peripheral blood neutrophils, changes in differential leukocyte count, and weight of immunocompetent organs.
It was found that changes in the immune response caused by “social” stress are multidirectional, which confirms the theory of stress-induced “immune imbalance”.
Semax acted as effective immune corrector restoring cellular and humoral immunogenesis reactions and phagocytic activity of neutrophils.
This attested to the presence of immunomodulating properties in Semax and necessitates further studies in this field.”
Semax has applications in treating stroke as it helps protect the brain from damage and improves recovery, thereby reducing the risk of future strokes.
It works by enhancing brain function, reducing inflammation, and promoting the repair of brain cells.
In fact, in a study with 187 patients who had cerebrovascular insufficiency (a condition where brain arteries are blocked, reducing blood flow), treatment with Semax slowed the disease’s progression and lowered the risk of stroke.
“One hundred and eighty-seven patients with different stages of cerebrovascular insufficiency (CI) have been examined.
A diagnosis of CI was based on the results of neurological and neuropsychological study, ultrasonic dopplerography, rheo- and encephalography, electrocardiography, brain MRI and eyegrounds examination.
Neurological scales were used for neurological status assessment and further data processing.
The study aimed at evaluation of tolerability and clinical efficacy of the medication and complications in CI course.
Semax treatment resulted in significant clinical improvement, stabilization of the disease progress and reduced a risk of stroke and transitory ischemic attacks in the disease course.
The drug is featured by minor percent of side-effects and is well tolerated by patients, including those of older age groups.”
Semax vs Selank Side Effects
Semax and Selank are generally safe when used as directed with few reported side effects.
Other biohackers who’ve tried Semax have shared some of their experiences with using the peptide.
Some have experienced headaches when exceeding the recommended dosage, although one individual found that their headache went away within 30 minutes after mistakenly taking a 24 mg dose.
However, peptide physician Dr. William Seeds suggests that surpassing the advised amount could diminish its effects.
Others have reported feeling anxious or sick after trying Semax, while some have noted no discernible effects (particularly if they’ve used similar stimulants previously).
Interestingly, there have been no reported withdrawal symptoms upon discontinuation.
However, Semax could potentially exacerbate feelings of anxiety in those sensitive to cortisol, and some users have described feeling spaced out post-administration.
Additionally, there’s the possibility of entering a “honeymoon phase” where the effects become less potent over time.
Although the connection is entirely anecdotal and has not happened to everyone, a few biohackers report experiencing hair loss due to increased BDNF production.
Yet there are enthusiastic fans of Selank who claim it comes with no nasty surprises.
Here are some anecdotal side effects of Selank that have been reported…
Some folks don’t notice any big changes in anxiety or mood, while others have noticed chances of allergic reactions.
Hair loss might be linked to increased BDNF production (although this has not been confirmed and unlikely as we KNOW the root cause of hair loss), and the peptide could cause problems for people with certain autoimmune disorders.
Some users have experienced brain fog or fatigue, and this might even ramp up anxiety for some.
Using Selank and Semax nasally can also sometimes cause sinus pain, nosebleeds, and irritation if not done correctly.
Make sure to follow the recommended dosages and properly administer them.
The truth is that the only way to find out how Selank and/or Semax affect you is by using them for a minimum of 2-4 weeks (but ideally 90 days) and then seeing how you feel.
Selank vs Semax Dosages
Let’s compare the different dosing approaches for both cognitive health peptides.
Selank Nasal Spray Dosing Protocol
While there hasn’t been enough human research on Selank to establish an official dosing schedule, a book published by Dr. William Seeds in 2020 has proposed a protocol based on available data and anecdotal evidence from patients using peptide therapy.
Starting Dose:
- Begin with the lowest effective dose, typically 300 mcg per day for subcutaneous injection.
- Take 750-1,000 mcg once a day via nasal spray, spread out over several doses if needed.
- Monitor your response and adjust the dose gradually by 100 to 250 mcg every few days if needed.
Nasal Administration:
- Daily doses can go up to 1,000 mcg without any reported side effects.
- For doses higher than 300 mcg, split the dose into multiple administrations throughout the day.
Dosage Schedule:
- Administer Selank for 12 weeks, followed by a 4-week break.
- This cycle can be repeated as necessary.
Take Selank consistently for several weeks or months to assess its effectiveness.
If you notice reduced effectiveness over time, consider taking breaks to prevent tolerance.
By following these guidelines, you can safely and effectively use Selank as a nasal spray to potentially enhance your cognitive function and overall well-being.
Semax Nasal Spray Dosing Protocol
In Russia, two formulations of intranasal Semax have been approved: a 0.1% solution and a 1% solution, each with specific indications and dosage guidelines.
0.1% Semax Nasal Drops:
- Mental Exhaustion: 400-900 mcg daily, divided into 2-3 doses for 3-5 days.
- Cognitive Issues in Children and Teenagers (7-18 years): 200-400 mcg daily, split into two doses for 30 days.
- Optic Nerve Ailments: 600-900 mcg daily, divided into 2-3 doses for 7-10 days.
- Memory-Related Cognitive Deficits: 200-2000 mcg per application, used four times daily for 10-14 days, totaling 800-8000 mcg daily.
The 0.1% formulation can be administered daily for up to 30-day cycles, especially in patients with glaucoma.
1% Semax Nasal Drops:
- Mild-Moderate Stroke: 2,000-3,000 mcg, taken 3-4 times daily at 3-4 hour intervals for 10 days, totaling 6,000-12,000 mcg daily.
- Severe Stroke: 3,000-4,000 mcg, taken 4-6 times daily at 2.5-3 hour intervals for up to 10 days, totaling 12,000-20,000 mcg daily
For mild-moderate stroke patients, a typical regimen involves a 10-day active period followed by a 20-day washout and then another 10-day active period.
Experimental Research Dosage (0.3% Semax Nasal Spray):
- Initial Dose: 600 mcg daily (2 pumps).
- Adjustment: Increase the dose based on individual response, taking up to 900 mcg daily (3 pumps).
- Study Duration: Up to 30 days for doses higher than 900 mcg daily, or 600 mcg daily for up to 60 days.
- Cycle: Ensure a rest period equivalent to the study duration following the experiment.
Forms and Administration
Selank Nasal Spray
Selank is ineffective when taken orally because it is quickly broken down in the stomach, making the nasal spray an effective method of administration.
The nasal spray is particularly fast-acting and easy to use, which enhances its nootropic effects.
This rapid action is due to the peptide’s quick passage from the nasal mucosa into the bloodstream, facilitated by the porosity of the endothelial membrane and high blood flow at the absorption site.
Additionally, Selank does not get metabolized at the absorption site and benefits from the large surface area of the nasal passages, ensuring efficient and swift absorption.
Therefore, using Selank as a nasal spray is the best way to experience its cognitive benefits.
Semax Nasal Spray
Like Selank, Semax is given as a nasal spray or subcutaneous injection.
Researchers believe that Semax moves quickly through the body via extraneuronal transport, which is why its effects are noticed within 15-30 minutes after intranasal use.
Injection
There are no official guidelines for how much injectable Semax and Selank to use, and it can be difficult to determine the optimal dose compared to the nasal spray version.
For biohackers aiming to boost thinking skills, a common plan is to inject 500 mcg to 1 mg of Semax subcutaneously each day, depending on how the person reacts.
This would last four to eight weeks assuming the use of one vial containing 30 doses of 1 mg per dose (or 60 doses of 500 mcg per dose).
For example, a subcutaneous injection of Selank at 100-300 mcg once per day may start working within 10 to 20 minutes in some people.
Can Selank and Semax Be Used Together?
The combination of Selank and Semax is effective for people seeking the following benefits:
- Improved mental clarity
- Better memory and focus
- Alleviated symptoms of anxiety and depression
- Accelerated nerve regeneration
- Improved neuromuscular performance
- Reducing neural inflammation
- Faster learning
A Redditor who uses Selank and Semax together reported improvements in his mental clarity, memory, and focus after using the peptide combination:
“So far, I have used them both at the same time almost every time. Selank to chill out, and Semax to keep me focused.
I just don’t notice enough of a negative effect from either to not want to use them both every time.
Unlike most things that help me focus, Semax doesn’t seem to overstimulate me, and unlike most things that help me chill out, Selank doesn’t dull me.”
Jay’s Closing Thoughts
I’m not personally a big user of nootropic peptides and I haven’t done much experimentation with either Semax or Selank
As of this writing, I AM heavily in favor of Tesofensine as my primary go-to agent for cognitive enhancement.
So much so to the point where it has replaced Modafinil in my supplement stack… which I used and heavily promoted for many years.
This is due to what I believe is its superior BDNF enhancement and promotion of the flow state for the highest levels of creativity.
However, don’t let my personal preferences stop you from using these peptides.
I AM likely to start experimenting with both peptides soon and in combination as the experiential data is awesomely exciting.
The numerous anecdotes from other biohackers show at the minimum they are worth an honest trial.
Start low, titrate the dose up slowly, and monitor both the benefits and side effects you experience.
Verdict: Choosing Semax or Selank Peptide Therapy
Choosing between Semax and Selank depends on what you want to achieve.
If you desire to boost your cognitive performance, Semax is your best option.
But if you desire to reduce stress/anxiety or lift your mood, Selank is the way to go.
Either way, make sure you’re always sourcing them from a trusted source to avoid possible risks and side effects.
I trust Limitless Life Nootropics because they are the biohacking industry’s only reliable vendor for 3rd-party tested research products.
They have the best formulations of therapeutic peptides available and no other vendor comes close to offering them at ultra-high levels of purity for reasonable prices.
Until Friday May 31st 2024 @ Midnight PST, get Selank or Semax for 25% OFF with code JayC
If you missed the deal above, use code JAY15 as always to get 15% off your order
But before you start injecting these peptides into your body recklessly, make sure you first read the Top 10 Mistakes People Make When Starting Therapeutic Peptides FREE PDF!
Seriously, this short e-book will save you a lot of wasted money and poorly spent time (not to mention preventing you from potential self-inflicted missteps).
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